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How Manavalan and Ramasamy's Physical Pharmaceutics Explains the Properties and Formulation of Drug Substances

- Importance and applications of physical pharmaceutics H2: Fundamental Properties of Drug Substances - Solubility and dissolution - Stability and degradation - Surface and interfacial phenomena - Rheology and flow properties - Micromeritics and particle size analysis - Complexation and protein binding H2: Formulation of Drug Substances into Dosage Forms - Factors affecting formulation design - Types and characteristics of dosage forms - Methods and equipment for preparation of dosage forms - Quality control and evaluation of dosage forms H2: Physical Pharmaceutics by Manavalan and Ramasamy - Overview and features of the book - Contents and structure of the book - Reviews and feedback on the book H2: Conclusion - Summary of the main points - Recommendations and future prospects Table 2: Article with HTML formatting What is Physical Pharmaceutics?

Physical pharmaceutics is a branch of pharmacy that deals with the physical and chemical properties of drug substances and their interactions with biological systems. It also involves the study of how these properties affect the formulation, manufacturing, stability, delivery, and performance of pharmaceutical products.

physical pharmaceutics manavalan

The importance and applications of physical pharmaceutics are manifold. It helps to understand the mechanisms of drug action, absorption, distribution, metabolism, and excretion. It also helps to design optimal dosage forms that can enhance the efficacy, safety, and convenience of drug administration. Moreover, it helps to ensure the quality, stability, and bioavailability of pharmaceutical products throughout their shelf life.

Fundamental Properties of Drug Substances

Drug substances are the active ingredients that produce the desired pharmacological effects in the body. They can be classified into different categories based on their chemical structure, origin, mode of action, therapeutic use, etc. However, regardless of their classification, they share some common physical and chemical properties that influence their behavior in various environments. Some of these properties are:

Solubility and dissolution

Solubility is the ability of a substance to dissolve in a solvent. Dissolution is the process of dissolving a substance in a solvent. Solubility and dissolution are important factors that determine the rate and extent of drug absorption in the body. The solubility of a drug substance depends on its polarity, molecular size, crystal structure, ionization state, temperature, pH, etc. The dissolution rate of a drug substance depends on its surface area, particle size, agitation, viscosity, etc.

To improve the solubility and dissolution rate of poorly soluble drugs, various techniques can be employed such as salt formation, co-solvency, complexation, micellization, nanonization, etc.

Stability and degradation